
After defeating D-Mob in the story's final battle, a one-on-one fight at the 125th Street Station, you decide to leave the underground fight scene for good. Ultimately, it is revealed that D-Mob was using you to take over the five boroughs, controlling New York City's underground, and that he was going to leave you to take the fall, leading police to your exact whereabouts.

is murdered by the hands of Crow, leaving D-Mob to step in and use you as his number one fighter. Manny takes you to O.G., your "mentor", who instructs you in how to fight to gain control of (take over) the five boroughs of New York City. However, instead of D-Mob being freed from police custody, like in Fight for NY, it is tattoo artist Manny who is saved from corrupt police officers. You still play a nameless up-and-coming gangsta brought into the world of underground street fighting after rescuing one of the game's personalities from trouble with the police. However, the game uses many of the same situations and characters from Fight for NY, which is the third game in the series, chronologically.

The game's story is a prequel to the events of Def Jam Vendetta. 5.6 Dragon House Fighters (Non-Joinable).4 Changed features from the original Fight for NY.
